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Guangzhou Kafen Biotech Co., Ltd.

Naloxone HCl, Naloxone Hydrochloride, Naloxone manufacturer / supplier in China, offering Quality Supply Naloxone HCl Hydrochloride Powder 357-08-4 with Safe Shipment, Sell High Quality Anti Oxidants Silicon Dioxide Powder Feed Additives, Digestive System Drugs Omeprazole for Treatment of Peptic Ulcer 73590-58-6 and so on.

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Supplier Homepage Product Pharmaceutical Intermediates Quality Supply Naloxone HCl Hydrochloride Powder 357-08-4 with Safe Shipment

Quality Supply Naloxone HCl Hydrochloride Powder 357-08-4 with Safe Shipment

FOB Price: US $10-100 / Bag
Min. Order: 1 Bag
Min. Order FOB Price
1 Bag US $10-100/ Bag
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Production Capacity: 5000kg/Month
Transport Package: Discreet
Payment Terms: T/T, Western Union, Money Gram, Bitcoin

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Basic Info
  • Model NO.: 357-08-4
  • Customized: Customized
  • Suitable for: Adult
  • Purity: >99%
  • CAS: 357-08-4
  • MW: 363.84
  • MP: 200-2050c
  • Delivery Time: Within 12 Hours After Receiving Your Payment
  • Specification: Qualified
  • HS Code: 3001200020
  • Powder: Yes
  • Certification: GMP, HSE, ISO 9001, USP, BP, Ukas
  • State: Solid
  • Name: Naloxone HCl
  • Mf: C19h22clno4
  • Einecs: 206-611-0
  • Shipment Way: EMS, HK Post, DHL, TNT, UPS, FedEx, Aramex
  • Trademark: kafenbio
  • Origin: Guangzhou
Product Description
1.Quick Details:
 
Product Name:Naloxone hydrochloride
Synonyms:NALOXONE HCL;NALOXONE HYDROCHLORIDE;(5ALPHA)-4,5-EPOXY-3,14-DIHYDRO-17-(2-PROPENYL)MORPHINAN-6-ONE HYDROCHLORIDE;4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride;17-allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-onehydrochloride;17-allyl-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-onhydrochloride;en1530;l-n-allyl-14-hydroxynordihydromorphinonehydrochloride
CAS:357-08-4
MF:C19H22ClNO4
MW:363.84
EINECS:206-611-0
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Opioid receptor and opioid-like receptor;Opioids;Chiral Reagents;Drug Analogues;API

2.Product Description:

Naloxone blocks or reverses the effects of opioid medication, including extreme drowsiness, slowed breathing, or loss of consciousness. An opioid is sometimes called a narcotic.

Naloxone is used to treat a narcotic overdose in an emergency situation. This medicine should not be used in place of emergency medical care for an overdose.Naloxone is also used to help diagnose whether a person has used an overdose of an opioid.

Naloxone is injected into a muscle, under the skin, or into a vein through an IV. The injection may be given by a healthcare provider, emergency medical provider, or a family member or caregiver who is trained to properly give a naloxone injection.

If you are a caregiver or family member giving a naloxone injection, read all instructions when you first get this medicine. If provided, use the "trainer" device to practice giving an injection so you will know how to do it in an emergency. Ask your doctor or pharmacist if you have any questions.

3.Product Usage:

Naloxone, sold under the brandname Narcan among others, is a medication used to block the effects of opioids, especially in overdose.Naloxone may be combined within the same pill as an opioid to decrease the risk of misuse. When given intravenously, it works within two minutes, and when injected into a muscle, it works within five minutes.The medication may also be used in the nose.The effects of naloxone last about half an hour to an hour.Multiple doses may be required, as the duration of action of most opioids is greater than that of naloxone.

Administration to opioid-dependent individuals may cause symptoms of opioid withdrawal, including restlessness, agitation, nausea, vomiting, a fast heart rate, and sweating. To prevent this, small doses every few minutes can be given until the desired effect is reached. In those with previous heart disease or taking medications that negatively affect the heart, further heart problems have occurred.It appears to be safe in pregnancy, after having been given to a limited number of women.Naloxone is a pure opioid antagonist. It works by reversing the depression of the central nervous system and respiratory system caused by opioids.

4.Function:

Since the duration of action of some narcotics may exceed that of naloxone, the patient should be kept under continued surveillance and repeated doses of naloxone should be administered as necessary.
Naloxone hydrochloride may be administered intravenously, intramuscularly or subcutaneously. The most rapid onset of action is achieved with the intravenous route and is recommended in emergency situations. Naloxone may be diluted for intravenous infusion by adding 2 mg naloxone hydrochloride to 500 mL of either normal saline or 5% dextrose. The resulting solution will contain 4mcg/mL of naloxone. Infusion should be commenced as soon as practicable after preparation of the mixture in order to reduce microbial hazards. Preparations not used within 24 hours should be discarded. The rate of infusion should be titrated against the response of the patient.
Adults
For the treatment of known opioid overdose, or as an aid in the diagnosis of suspected opioid overdose:Initial dose is 0.4 - 2.0 mg intravenously given at 2 to 3 minute intervals if necessary. If there is no response after a total dose of 10 mg has been given, the depressed condition may be due to a drug or disease process not responsive to naloxone. When the intravenous route cannot be used, the drug may be given by intramuscular or subcutaneous injection.
For use postoperatively to reverse central depression caused by opioids used during surgery:
The usual dose is 0.1 to 0.2 mg intravenously given at 2 to 3 minute intervals. The aim is to achieve an optimum respiratory response whilst maintaining adequate analgesia. Additional doses may be necessary at 1 to 2 hour intervals depending on the response of the patient and the dose and duration of action of the opioid administered. Supplemental intramuscular doses have been shown to produce a longer lasting effect.
For the treatment of sever alcoholism, initial dose is 0.8-1.2mg, one hour later 0.4-0.8mg is given.
Children
The usual initial dose for children is 10 mcg/kg body weight (0.01 mg/kg) given intravenously. If the dose does not result in adequate clinical improvement, a subsequent dose of 100 mcg/kg (0.1 mg/kg) may be given. If the intravenous route is not available, naloxone may be given intramuscularly or subcutaneously in divided doses. If necessary, naloxone can be diluted with Water for Injections.
For use postoperatively to reverse central depression caused by opioids used during surgery: Take reference of the suggestions and precautions of adult use postoperatively to reverse central depression caused by opioids used during surgery. After initial reverse of the respiration depression, a dose of 0.1 to 0.2 mg is given intravenously at 2 to 3 minute intervals till expected reverse is achieved.
Neonates
An injection of 10 mcg/kg (0.01 mg/kg) may be given to the infant by the intramuscular, intravenous or subcutaneous route and repeated at intervals of 2 to 3 minutes if necessary.
Alternatively, for a more prolonged action, a single intramuscular dose of 60 mcg/kg (0.06 mg/kg) may be given at birth.
For reversing opioid-induced depression, an initial dosage of 0.01mg/kg may be administered intravenously, intramuscularly or subcutaneously. Repeated use can take reference of the instruction on adult use postoperatively to reverse central depression caused by opioids used during surgery.
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