Follistatin 344 Follistatin344 Follistatin 1mg / Vial Lyophilized Powder
|1-9 10-99 100+|
|FOB Unit Price:||US $2 US $1.5 US $1|
|Purchase Qty. (GRAMS)||FOB Unit Price|
|Transport Package:||Discreet Packing as Customer′s Requirement|
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- Model NO.: Follistatin 344
- Customized: Customized
- Suitable for: Elderly, Adult, Bodybuilder
- Purity: >99%
- Payment Terms: Wu, Mg, Bitcoin and Bank Transfer
- Form: Powder
- Storage: Keep Cool
- Specification: CAS: None
- HS Code: 3001200090
- Powder: Yes
- Certification: GMP, HSE, ISO 9001, USP, BP, Kosher
- State: Solid
- Shipping Ways: EMS, DHL, FedEx, UPS, Aramex and Ect
- Assay: 99.99%
- Character: White Lyophilized Powder
- Trademark: Kafen Biotech
- Origin: China
Name: Follistatin 344
Synonyms: FST, FS, Activin-binding protein.
Appearance: Sterile Filtered White Lyophilized (Freeze-Dried)
Purity (by HPLC): 99.00%
Source: Escherichia Coli
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation: Lyophilized from a concentrated (1mg / ml) solution containing no additives.
Solubility: It is recommended to reconstitute the lyophilized Follistatin in sterile 18MΩ-cm H2O not less than 100μg / ml, which can then be further diluted to other aqueous solutions.
Stability: Lyophilized Follistatin although stable at room temperature for 3 weeks.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC (b) Analysis by SDS-PAGE..
Storage Conditions: Aviod Shunshine and Keeping Stoppered
Packing: 1mg / vial, 2mg / vial
Follistatin is being studied for its role in regulation of muscle growth in mice, as an antagonist to myostatin (also known as GDF-8, a TGF superfamily member) which inhibits excessive muscle growth. Lee & McPherron demonstrated that inhibition of GDF-8, either by genetic elimination (knockout mice) or by increasing the amount of follistatin, resulted in greatly increased muscle mass.In 2009, research with macaque monkeys demonstrated that regulating follistatin via gene therapy also resulted in muscle growth and increases in strength. This research paves the way for human clinical trials, which are hoped to begin in the summer of 2010 on Inclusion body myositis.
A study has also shown that increased levels of follistatin, by leading to increased muscle mass of certain core muscular groups, can increase life expectancy in cases of spinal muscular atrophy (SMA) in animal models.
It is also being investigated for its involvement in polycystic ovary syndrome (PCOS), though there is debate as to its direct role in this infertility disease.
Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing myostatin. Scientists first identified follistatin while examining porcine (re: pig) follicular fluid in the ovaries.
Follistatin is naturally found in the skeletal muscle of almost all mammals with advanced or developed characteristics, such as humans, rodents, and cows. Follistatin is high in the
non-essential amino acid cystine but unlike most proteins discussed in the fitness world, follistatin has carbohydrates attached to it.
Follistatin, specifically Follistatin 344 (FS344), quickly gained popularity in the bodybuilding community as a potential supplement to rapidly increase lean tissue mass. Another protein, follistatin-related gene (FLRG) acts on similar pathways as FS344 regarding its muscle building properties. Increased lean tissue mass could give a bodybuilder an advantage in a competitive setting and be the differentiating factor between first and second place.
Follistatin (FS) was initially identified as a follicle-stimulating hormone inhibiting substance found in ovarian follicular fluid. FS is a high-affinity activin-binding protein that can act as an activin antagonist. Two alternatively spliced follistatin mRNAs exist, encoding mature FS with 288 amino acid (aa) residues (FS-288) and 315 aa residues (FS-315). Natural FS purified from porcine ovaries is primarily a carboxy-terminal truncated form of FS-315 composed of 300 aa residues.
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. Follistatin binds directly to activin and functions as an activin antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh).
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Follistatin 315 primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a
particular focus on activin, a paracrine hormone.
Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be
stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product
contain a precipitate we recommend microcentrifugation before use.
We accept any Qty you require, grams to kilograms.
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